DNA-Encoded Libraries (DELs) involve the chemical barcoding of unique small molecules with unique DNA sequences. A beneficial feature of DELs are their ability to be rapidly screened against a target protein of interest using a simple affinity-based selection format to identify potent binders. Additionally, compared to more conventional forms of screening, DELs offer the advantage of sampling a wider chemical space (103-106 more molecules) at a fraction of the cost and time. These features make DELs particularly attractive within the academic community where the target scope can be broad, but also the cost effectiveness of screening is a major limiting factor. We have generated a library containing over 7-billion DNA-encoded molecules which is the largest academic collection in the world. We have screened this DEL against emerging academic targets as well as highly validated disease targets of considerable importance to human health. The lecture will focus on these DEL screening efforts and key learnings from them. It will additionally describe future innovations to further expand the utility of the DEL platform.