Topological band theory transformed our understanding of crystalline materials by classifying the connectivity and crossings of electronic energy levels. Despite many fundamental questions, extending these concepts to molecular systems has recently attracted significant interest. Reactions governed by orbital symmetry conservation are ideal candidates, as they classify pathways as symmetry-allowed or symmetry-forbidden depending on whether molecular orbitals cross along the reaction coordinate. However, the presence of strong electronic correlations in these reactions invalidate the framework underlying topological band theory, preventing direct generalization. Here, we introduce a formalism in terms of Green's functions to classify orbital symmetry controlled reactions even in the presence of strong electronic correlations. Focusing on prototypical 4π electrocyclizations, I will discuss how symmetry-forbidden pathways are characterized by crossings of Green's function zeros, in stark contrast to the crossings of poles as predicted by molecular-orbital theory. I introduce a topological invariant that identifies these symmetry protected crossings of both poles and zeros along a reaction coordinate  and outline generalizations of this approach to reactions without any conserved spatial symmetries along the reaction path. This work lays the groundwork for systematic application of modern topological methods to chemical reactions and can be extended to reactions involving different spin states or excited states.