Video director Michel Gondry and scriptwriter Charles Kaufman -- who shot to fame after penning Being John Malkovich -- collaborate on this bizarre fable about human behavior in and out of society. The film opens by quickly introducing the three leads -- Lila (Patricia Arquette) who is locked away in prison; Puff (Rhys Ifans) who is testifying before Congress; and Nathan Bronfman (Tim Robbins) who is sitting in a glowing white afterlife waiting room with a bullet hole in his head. Rewinding to the beginning of the story, the film shows Lila as a girl about to enter womanhood. Unfortunately, puberty goes horribly awry and she starts to grow thick hair all over her body. After performing as Queen Kong in a circus freak show, she chucks it all and goes to live in the forest, where she becomes the best-selling author of a misanthropic hard-line ecological tome.

At age 30, her itch for male companionship becomes overwhelming and she ventures back into the city. She is helped by electrolysis guru Louise (Rosie Perez), who not only makes Lila presentable to society, but introduces her to Nathan, a 35-year-old virgin who, as a scientist, has devoted his life to teaching table etiquette to lab mice. While showing Nathan the joys of the wild outdoors, Lila and her new beau discover an extremely hirsute feral man whom they dub Puff. Placing him a cage in his lab, Nathan sets out to teach Puff the ways of polite society while dreaming of fame and fortune.