Post-synthetic transformations are a means to design nanoparticles that would be difficult to synthesize directly due to their shape, phase, or the presence of multiple chemical components. We have developed two anionic post-synthetic transformations of copper sulfide nanorods. Tellurium exchange creates Cu2-xS/Cu2-xTe nanoheterostructures with various regioselectivities. Selenium transformations proceed either through a dissolution/reprecipitation mechanism to create Cu2-xS/Cu2-xSe nanoheterostructures with various shapes or through an anion exchange mechanism to create Cu2-x(S,Se) alloyed nanorods. Here we present our latest work to understand how we can extend these anionic post-synthetic transformations to develop a variety of nanoheterostructures. We have investigated the results of consecutive cation and anion transformations to reveal new materials design rules. Combination of tellurium anion exchange with cadmium cation exchange alters ion mobility and reveals a combined regioselectivity that is distinct from each individual transformation. Combination of selenium transformation with cadmium cation exchange reveals the importance of the order of when applying consecutive post-synthetic transformations.